Zile Muri-yo was a small, unmapped jungle island off the southern coast of Haiti, about two miles south of Terre Rouge. Its local name had the same meaning as its French name Isle de Mort (Island of the Dead or Island of Death in English). While home to Efreye Village and a few sisal plantations, most of the island was covered by thick jungle and rough terrain. The island was about 5 kilometers long and 2 kilometers wide, but travel on the island was slow due to dense vegetation and steep gorges. Frequent rains kept the vegetation constantly growing and the rivers swift and dangerous. Much of the island's population knew that zombis were found on the island, and the sole store on the island kept a large stock of ammunition.
In 1943, Indiana Jones and George McHale traveled to the island in search of the Heart of Darkness, a legendary black pearl. Pursuing them were Japanese and German forces, as well as Boukman, a powerful bokor, and his zombi slaves.